Anti-COPS3 antibody (194-423) (STJ29097)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COPS3 (194-423) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COPS3 |
| Gene ID | 8533 |
| Uniprot ID | CSN3_HUMAN |
| Immunogen Region | 194-423 |
| Immunogen Sequence | GLKNFERALYFYEQAITTPA MAVSHIMLESYKKYILVSLI LLGKVQQLPKYTSQIVGRFI KPLSNAYHELAQVYSTNNPS ELRNLVNKHSETFTRDNNMG LVKQCLSSLYKKNIQRLTKT FLTLSLQDMASRVQLSGPQE AEKYVLHMIEDGEIFASINQ KDGMVSFHDNPEKYNNPAML HNIDQEMLKCIELDERLKAM DQEITVNPQFVQKSMGSQED DSGNKPSSYS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 194-423 of human COPS3 (NP_003644.2). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at high level in heart and skeletal muscle. |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 3Sgn3Signalosome Subunit 3Jab1-Containing Signalosome Subunit 3 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 3 antibodyAnti-Sgn3 antibodyAnti-Signalosome Subunit 3 antibodyAnti-Jab1-Containing Signalosome Subunit 3 antibodyAnti-COPS3 antibodyAnti-CSN3 antibody |
Information sourced from Uniprot.org