| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Copine 1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.1-0.3µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CPNE1 |
| Gene ID: |
8904 |
| Uniprot ID: |
CPNE1_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_690902.1; NP_003906.2 |
| Specificity: |
This antibody is expected to recognize isoform a and b (NP_003906.2; NP_690902.1). Reported variants represent identical protein: NP_690905.1, NP_690902.1, NP_690903.1, NP_690906.1, NP_690904.1, NP_690907.1, NP_690908.1. |
| Immunogen Sequence: |
APLKPLPPSAKDPA |
| Function | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation.induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL. |
| Protein Name | Copine-1Chromobindin 17Copine I |
| Database Links | Reactome: R-HSA-1483206Reactome: R-HSA-6798695 |
| Cellular Localisation | NucleusCytoplasmCell MembraneTranslocates To The Cell Membrane In A Calcium-Dependent Manner |
| Alternative Antibody Names | Anti-Copine-1 antibodyAnti-Chromobindin 17 antibodyAnti-Copine I antibodyAnti-CPNE1 antibodyAnti-CPN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
