• STJ70972 (0. 3µg/ml) staining of Human Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • STJ70972 (4µg/ml) staining of paraffin embedded Human Cerebellum. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.

Anti-COMT antibody (Internal) (STJ70972)

SKU:
STJ70972-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-COMT (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.03-0.1µg/ml
IHC-2-4µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: COMT
Gene ID: 1312
Uniprot ID: COMT_HUMAN
Immunogen Region: Internal
Accession Number: NP_000745.1; NP_009294.1
Specificity: This antibody is expected to recognise both reported isoforms (NP_000745.1 and NP_009294.1)
Immunogen Sequence: QDIIPQLKKKYDVD
Post Translational Modifications The N-terminus is blocked.
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Protein Name Catechol O-Methyltransferase
Database Links Reactome: R-HSA-156581
Reactome: R-HSA-379397
Reactome: R-HSA-379398
Reactome: R-HSA-9679191
Cellular Localisation Isoform Soluble: Cytoplasm
Isoform Membrane-Bound: Cell Membrane
Single-Pass Type Ii Membrane Protein
Extracellular Side
Alternative Antibody Names Anti-Catechol O-Methyltransferase antibody
Anti-COMT antibody

Information sourced from Uniprot.org

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