Anti-COMMD5 antibody (47-97) (STJA0006362)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human COMD5 AA range: 47-97
General Information
| Short Description | Rabbit polyclonal anti-COMM domain-containing protein 5 (47-97) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COMMD5 |
| Gene ID | 28991 |
| Uniprot ID | COMD5_HUMAN |
| Immunogen | Synthesized peptide derived from human COMD5 AA range: 47-97 |
| Immunogen Region | 47-97 |
| Specificity | This antibody detects endogenous levels of human COMD5 |
Additional Info
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
| Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 5 antibodyAnti-Hypertension-Related Calcium-Regulated Gene Protein antibodyAnti-Hcarg antibodyAnti-COMMD5 antibodyAnti-HT002 antibody |
Information sourced from Uniprot.org