Anti-COMMD5 antibody (1-224) (STJ118945)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COMMD5 (1-224) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COMMD5 |
| Gene ID | 28991 |
| Uniprot ID | COMD5_HUMAN |
| Immunogen Region | 1-224 |
| Immunogen Sequence | MSAVGAATPYLHHPGDSHSG RVSFLGAQLPPEVAAMARLL GDLDRSTFRKLLKFVVSSLQ GEDCREAVQRLGVSANLPEE QLGALLAGMHTLLQQALRLP PTSLKPDTFRDQLQELCIPQ DLVGDLASVVFGSQRPLLDS VAQQQGAWLPHVADFRWRVD VAISTSALARSLQPSVLMQL KLSDGSAYRFEVPTAKFQEL RYSVALVLKEMADLEKRCER RLQD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human COMMD5 (NP_054785.2). |
Additional Info
| Tissue Specificity | Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
| Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 5 antibodyAnti-Hypertension-Related Calcium-Regulated Gene Protein antibodyAnti-Hcarg antibodyAnti-COMMD5 antibodyAnti-HT002 antibody |
Information sourced from Uniprot.org