Anti-COMMD3 antibody (24-74 aa) (STJ195817)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human COMD3 at the amino acid range 24-74
General Information
| Short Description | Rabbit polyclonal anti-COMM domain-containing protein 3 (24-74 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COMMD3 |
| Gene ID | 23412 |
| Uniprot ID | COMD3_HUMAN |
| Immunogen | Synthesized peptide derived from the human COMD3 at the amino acid range 24-74 |
| Immunogen Region | 24-74 aa |
| Specificity | This antibody detects endogenous levels of COMD3 at Human/Mouse/Rat |
Additional Info
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. |
| Protein Name | Comm Domain-Containing Protein 3Protein BupProtein Pil |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 3 antibodyAnti-Protein Bup antibodyAnti-Protein Pil antibodyAnti-COMMD3 antibodyAnti-BUP antibodyAnti-C10orf8 antibody |
Information sourced from Uniprot.org