| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-COMM domain-containing protein 3 (24-74 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COMMD3 |
| Gene ID: | 23412 |
| Uniprot ID: | COMD3_HUMAN |
| Immunogen Region: | 24-74 aa |
| Specificity: | This antibody detects endogenous levels of COMD3 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human COMD3 at the amino acid range 24-74 |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. |
| Protein Name | Comm Domain-Containing Protein 3Protein BupProtein Pil |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 3 antibodyAnti-Protein Bup antibodyAnti-Protein Pil antibodyAnti-COMMD3 antibodyAnti-BUP antibodyAnti-C10orf8 antibody |
Information sourced from Uniprot.org
