Anti-COLEC11 antibody (26-271) (STJ26983)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COLEC11 (26-271) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COLEC11 |
| Gene ID | 78989 |
| Uniprot ID | COL11_HUMAN |
| Immunogen Region | 26-271 |
| Immunogen Sequence | QPAGDDACSVQILVPGLKGD AGEKGDKGAPGRPGRVGPTG EKGDMGDKGQKGSVGRHGKI GPIGSKGEKGDSGDIGPPGP NGEPGLPCECSQLRKAIGEM DNQVSQLTSELKFIKNAVAG VRETESKIYLLVKEEKRYAD AQLSCQGRGGTLSMPKDEAA NGLMAAYLAQAGLARVFIGI NDLEKEGAFVYSDHSPMRTF NKWRSGEPNNAYDEEDCVEM VASGGWNDVACHTTMYFMC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-271 of human COLEC11 (NP_076932.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level). |
| Function | Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. |
| Protein Name | Collectin-11Collectin Kidney Protein 1Cl-K1 |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-3000480 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Collectin-11 antibodyAnti-Collectin Kidney Protein 1 antibodyAnti-Cl-K1 antibodyAnti-COLEC11 antibodyAnti-UNQ596 antibodyAnti-PRO1182 antibody |
Information sourced from Uniprot.org