Anti-COL4A3BP antibody (369-598) (STJ117571)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COL4A3BP (369-598) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CERT1 |
| Gene ID | 10087 |
| Uniprot ID | CERT_HUMAN |
| Immunogen Region | 369-598 |
| Immunogen Sequence | QKVEEMVQNHMTYSLQDVGG DANWQLVVEEGEMKVYRREV EENGIVLDPLKATHAVKGVT GHEVCNYFWNVDVRNDWETT IENFHVVETLADNAIIIYQT HKRVWPASQRDVLYLSVIRK IPALTENDPETWIVCNFSVD HDSAPLNNRCVRAKINVAMI CQTLVSPPEGNQEISRDNIL CKITYVANVNPGGWAPASVL RAVAKREYPKFLKRFTSYVQ EKTAGKPILF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 369-598 of human COL4A3BP (NP_112729.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
| Function | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
| Protein Name | Ceramide Transfer ProteinHcertCollagen Type Iv Alpha-3-Binding ProteinGoodpasture Antigen-Binding ProteinGpbpStart Domain-Containing Protein 11Stard11Star-Related Lipid Transfer Protein 11 |
| Database Links | Reactome: R-HSA-1660661 Q9Y5P4-2 |
| Cellular Localisation | CytoplasmGolgi ApparatusEndoplasmic ReticulumPreferentially Localized To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Ceramide Transfer Protein antibodyAnti-Hcert antibodyAnti-Collagen Type Iv Alpha-3-Binding Protein antibodyAnti-Goodpasture Antigen-Binding Protein antibodyAnti-Gpbp antibodyAnti-Start Domain-Containing Protein 11 antibodyAnti-Stard11 antibodyAnti-Star-Related Lipid Transfer Protein 11 antibodyAnti-CERT1 antibodyAnti-CERT antibodyAnti-COL4A3BP antibodyAnti-STARD11 antibody |
Information sourced from Uniprot.org