| Short Description : | Rabbit polyclonal anti-Collagen alpha-1XXV chain (101-150 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COL25A1 |
| Gene ID: | 84570 |
| Uniprot ID: | COPA1_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Collagen XXV alpha1 at the amino acid range 101-150 |
| Immunogen Region: | 101-150 aa |
| Specificity: | COL25A1 Polyclonal Antibody detects endogenous levels of COL25A1 protein. |
| Post Translational Modifications | Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on 11% of proline residues and 49% of lysine residues. |
| Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Protein Name | Collagen Alpha-1(Xxv ChainAlzheimer Disease Amyloid-Associated ProteinAmyClac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque ComponentClac |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1650814Reactome: R-HSA-8948216 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinAfter Proteolytic CleavageClac Is Secreted |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xxv Chain antibodyAnti-Alzheimer Disease Amyloid-Associated Protein antibodyAnti-Amy antibodyAnti-Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component antibodyAnti-Clac antibodyAnti-COL25A1 antibody |
Information sourced from Uniprot.org
