| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COIL |
| Gene ID: | 8161 |
| Uniprot ID: | COIL_HUMAN |
| Immunogen Region: | 297-576 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human Coilin (NP_004636.1). |
| Immunogen Sequence: | KLGFSLTPSKGKTSGTTSSS SDSSAESDDQCLMSSSTPEC AAGFLKTVGLFAGRGRPGPG LSSQTAGAAGWRRSGSNGGG QAPGASPSVSLPASLGRGWG REENLFSWKGAKGRGMRGRG RGRGHPVSCVVNRSTDNQRQ QQLNDVVKNSSTIIQNPVET PKKDYSLLPLLAAAPQVGEK IAFKLLELTSSYSPDVSDYK EGRILSHNPETQQVDIEILS SLPALREPGKFDLVYHNEN |
| Tissue Specificity | Found in all the cell types examined. |
| Post Translational Modifications | Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs. Phosphorylated by VRK1. Phosphorylation during mitosis is associated with disassembly of CBs. |
| Function | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. |
| Protein Name | CoilinP80-Coilin |
| Cellular Localisation | NucleusCajal Body |
| Alternative Antibody Names | Anti-Coilin antibodyAnti-P80-Coilin antibodyAnti-COIL antibodyAnti-CLN80 antibody |
Information sourced from Uniprot.org