| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COASY (345-564) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COASY |
| Gene ID: |
80347 |
| Uniprot ID: |
COASY_HUMAN |
| Immunogen Region: |
345-564 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human CoA synthase (COASY ) (NP_079509.5). |
| Immunogen Sequence: |
LRPPYERPELPTCLYVIGLT GISGSGKSSIAQRLKGLGAF VIDSDHLGHRAYAPGGPAYQ PVVEAFGTDILHKDGIINRK VLGSRVFGNKKQLKILTDIM WPIIAKLAREEMDRAVAEGK RVCVIDAAVLLEAGWQNLVH EVWTAVIPETEAVRRIVERD GLSEAAAQSRLQSQMSGQQL VEQSHVVLSTLWEPHITQRQ VEKAWALLQKRIPKTHQALD |
| Tissue Specificity | Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. |
| Function | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain.the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. |
| Protein Name | Bifunctional Coenzyme A SynthaseCoa SynthaseNbpPov-2 Includes - Phosphopantetheine AdenylyltransferaseDephospho-Coa PyrophosphorylasePantetheine-Phosphate AdenylyltransferasePpat - Dephospho-Coa KinaseDpckDephosphocoenzyme A KinaseDpcoak |
| Database Links | Reactome: R-HSA-196783 |
| Cellular Localisation | CytoplasmMitochondrion MatrixThe Protein Is Mainly Present In The Mitochondrial MatrixProbably Anchored To The Inner Mitochondrial MembraneBut Is Also Present In Cell Lysate |
| Alternative Antibody Names | Anti-Bifunctional Coenzyme A Synthase antibodyAnti-Coa Synthase antibodyAnti-Nbp antibodyAnti-Pov-2 Includes - Phosphopantetheine Adenylyltransferase antibodyAnti-Dephospho-Coa Pyrophosphorylase antibodyAnti-Pantetheine-Phosphate Adenylyltransferase antibodyAnti-Ppat - Dephospho-Coa Kinase antibodyAnti-Dpck antibodyAnti-Dephosphocoenzyme A Kinase antibodyAnti-Dpcoak antibodyAnti-COASY antibodyAnti-PSEC0106 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
