Anti-COASY antibody (345-564) (STJ114072)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COASY (345-564) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COASY |
| Gene ID | 80347 |
| Uniprot ID | COASY_HUMAN |
| Immunogen Region | 345-564 |
| Immunogen Sequence | LRPPYERPELPTCLYVIGLT GISGSGKSSIAQRLKGLGAF VIDSDHLGHRAYAPGGPAYQ PVVEAFGTDILHKDGIINRK VLGSRVFGNKKQLKILTDIM WPIIAKLAREEMDRAVAEGK RVCVIDAAVLLEAGWQNLVH EVWTAVIPETEAVRRIVERD GLSEAAAQSRLQSQMSGQQL VEQSHVVLSTLWEPHITQRQ VEKAWALLQKRIPKTHQALD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human CoA synthase (COASY ) (NP_079509.5). |
Additional Info
| Tissue Specificity | Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. |
| Function | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain.the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. |
| Protein Name | Bifunctional Coenzyme A SynthaseCoa SynthaseNbpPov-2 Includes - Phosphopantetheine AdenylyltransferaseDephospho-Coa PyrophosphorylasePantetheine-Phosphate AdenylyltransferasePpat - Dephospho-Coa KinaseDpckDephosphocoenzyme A KinaseDpcoak |
| Database Links | Reactome: R-HSA-196783 |
| Cellular Localisation | CytoplasmMitochondrion MatrixThe Protein Is Mainly Present In The Mitochondrial MatrixProbably Anchored To The Inner Mitochondrial MembraneBut Is Also Present In Cell Lysate |
| Alternative Antibody Names | Anti-Bifunctional Coenzyme A Synthase antibodyAnti-Coa Synthase antibodyAnti-Nbp antibodyAnti-Pov-2 Includes - Phosphopantetheine Adenylyltransferase antibodyAnti-Dephospho-Coa Pyrophosphorylase antibodyAnti-Pantetheine-Phosphate Adenylyltransferase antibodyAnti-Ppat - Dephospho-Coa Kinase antibodyAnti-Dpck antibodyAnti-Dephosphocoenzyme A Kinase antibodyAnti-Dpcoak antibodyAnti-COASY antibodyAnti-PSEC0106 antibody |
Information sourced from Uniprot.org