Anti-CNOT4 antibody (61-110 aa) (STJ92366)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CNOT4 at the amino acid range 61-110
General Information
| Short Description | Rabbit polyclonal anti-CCR4-NOT transcription complex subunit 4 (61-110 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNOT4 |
| Gene ID | 4850 |
| Uniprot ID | CNOT4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CNOT4 at the amino acid range 61-110 |
| Immunogen Region | 61-110 aa |
| Specificity | CNOT4 Polyclonal Antibody detects endogenous levels of CNOT4 protein. |
Additional Info
| Function | Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 4Ccr4-Associated Factor 4E3 Ubiquitin-Protein Ligase Cnot4Potential Transcriptional Repressor Not4hpRing-Type E3 Ubiquitin Transferase Cnot4 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 4 antibodyAnti-Ccr4-Associated Factor 4 antibodyAnti-E3 Ubiquitin-Protein Ligase Cnot4 antibodyAnti-Potential Transcriptional Repressor Not4hp antibodyAnti-Ring-Type E3 Ubiquitin Transferase Cnot4 antibodyAnti-CNOT4 antibodyAnti-NOT4 antibody |
Information sourced from Uniprot.org