Anti-CNOT3 antibody (STJA0007308)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CNOT3
General Information
| Short Description | Rabbit polyclonal anti-CCR4-NOT transcription complex subunit 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNOT3 |
| Gene ID | 4849 |
| Uniprot ID | CNOT3_HUMAN |
| Immunogen | Synthesized peptide derived from human CNOT3 |
| Specificity | This antibody detects endogenous levels of CNOT3 at Human, Mouse |
Additional Info
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation.may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 3Ccr4-Associated Factor 3Leukocyte Receptor Cluster Member 2 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleusP-BodyNanos2 Promotes Its Localization To P-Body |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 3 antibodyAnti-Ccr4-Associated Factor 3 antibodyAnti-Leukocyte Receptor Cluster Member 2 antibodyAnti-CNOT3 antibodyAnti-KIAA0691 antibodyAnti-LENG2 antibodyAnti-NOT3 antibody |
Information sourced from Uniprot.org