Anti-CNGA3 antibody (STJ13100887)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human CNGA3 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CNGA3 for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CNGA3 |
| Gene ID | 1261 |
| Uniprot ID | CNGA3_HUMAN |
| Immunogen | A synthetic peptide from human CNGA3 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for CNGA3. |
Additional Info
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-3Cng Channel Alpha-3Cng-3Cng3Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-3 antibodyAnti-Cng Channel Alpha-3 antibodyAnti-Cng-3 antibodyAnti-Cng3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 antibodyAnti-CNGA3 antibodyAnti-CNCG3 antibody |
Information sourced from Uniprot.org