| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CNGA3 (1-165) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNGA3 |
| Gene ID: |
1261 |
| Uniprot ID: |
CNGA3_HUMAN |
| Immunogen Region: |
1-165 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human CNGA3 (NP_001289.1). |
| Immunogen Sequence: |
MAKINTQYSHPSRTHLKVKT SDRDLNRAENGLSRAHSSSE ETSSVLQPGIAMETRGLADS GQGSFTGQGIARLSRLIFLL RRWAARHVHHQDQGPDSFPD RFRGAELKEVSSQESNAQAN VGSQEPADRGRSAWPLAKCN TNTSNNTEEEKKTKKKDAIV VDPSS |
| Tissue Specificity | Prominently expressed in retina. |
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
| Protein Name | Cyclic Nucleotide-Gated Cation Channel Alpha-3Cone Photoreceptor Cgmp-Gated Channel Subunit AlphaCyclic Nucleotide-Gated Channel Alpha-3Cng Channel Alpha-3Cng-3Cng3 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Cation Channel Alpha-3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha antibodyAnti-Cyclic Nucleotide-Gated Channel Alpha-3 antibodyAnti-Cng Channel Alpha-3 antibodyAnti-Cng-3 antibodyAnti-Cng3 antibodyAnti-CNGA3 antibodyAnti-CNCG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
