Anti-CNGA3 antibody (1-165) (STJ116197)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CNGA3 (1-165) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNGA3 |
| Gene ID | 1261 |
| Uniprot ID | CNGA3_HUMAN |
| Immunogen Region | 1-165 |
| Immunogen Sequence | MAKINTQYSHPSRTHLKVKT SDRDLNRAENGLSRAHSSSE ETSSVLQPGIAMETRGLADS GQGSFTGQGIARLSRLIFLL RRWAARHVHHQDQGPDSFPD RFRGAELKEVSSQESNAQAN VGSQEPADRGRSAWPLAKCN TNTSNNTEEEKKTKKKDAIV VDPSS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human CNGA3 (NP_001289.1). |
Additional Info
| Tissue Specificity | Prominently expressed in retina. |
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-3Cng Channel Alpha-3Cng-3Cng3Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-3 antibodyAnti-Cng Channel Alpha-3 antibodyAnti-Cng-3 antibodyAnti-Cng3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 antibodyAnti-CNGA3 antibodyAnti-CNCG3 antibody |
Information sourced from Uniprot.org