| Short Description : | Rabbit monoclonal Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM13196 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:1000-1:5000IF/ICC, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMTM6 |
| Gene ID: | 54918 |
| Uniprot ID: | CKLF6_HUMAN |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Immunogen Sequence: | Human |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 6Chemokine-Like Factor Superfamily Member 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCo-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibodyAnti-Chemokine-Like Factor Superfamily Member 6 antibodyAnti-CMTM6 antibodyAnti-CKLFSF6 antibody |
Information sourced from Uniprot.org
