Anti-CMTM6 antibody [IHC700] (STJA0042037)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-CMTM6 for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC700 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Dilution Range | 1:50-1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Gene Symbol | CMTM6 |
| Gene ID | 54918 |
| Uniprot ID | CKLF6_HUMAN |
| Specificity | Tested and validated on tonsil tissue. |
Additional Info
| Tissue Specificity | Expressed in the leukocytes, placenta and testis. |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 6Chemokine-Like Factor Superfamily Member 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCo-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibodyAnti-Chemokine-Like Factor Superfamily Member 6 antibodyAnti-CMTM6 antibodyAnti-CKLFSF6 antibody |
Information sourced from Uniprot.org