Anti-CLPX antibody (534-633) [S4090RM] (STJ11104090)

Name: Anti-CLPX antibody (534-633) [S4090RM] (STJ11104090)
SKU: STJ11104090
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104090

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Short Description	Rabbit monoclonal Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like-Mitochondrial (534-633) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S4090RM
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CLPX
Gene ID	10845
Uniprot ID	CLPX_HUMAN
Immunogen Region	534-633
Immunogen Sequence	SMDKCELNVTEDALKAIARL ALERKTGARGLRSIMEKLLL EPMFEVPNSDIVCVEVDKEV VEGKKEPGYIRAPTKESSEE EYDSGVEEEGWPRQADAANS
Specificity	A synthetic peptide corresponding to a sequence within amino acids 534-633 of human CLPX (O76031).

Tissue Specificity	Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
Function	ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity.
Protein Name	Atp-Dependent Clpx-Like Chaperone - Mitochondrial Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - Mitochondrial Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X
Database Links	Reactome: R-HSA-9837999
Cellular Localisation	Mitochondrion Mitochondrion Matrix Mitochondrion Nucleoid
Alternative Antibody Names	Anti-Atp-Dependent Clpx-Like Chaperone - Mitochondrial antibody Anti-Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - Mitochondrial antibody Anti-Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X antibody Anti-CLPX antibody

Information sourced from Uniprot.org