Anti-CLPTM1 antibody [SAA1543] (STJA0019971)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Putative Lipid Scramblase Clptm1 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1543 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | CLPTM1 |
| Gene ID | 1209 |
| Uniprot ID | CLPT1_HUMAN |
Additional Info
| Function | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development. |
| Protein Name | Putative Lipid Scramblase Clptm1Cleft Lip And Palate Transmembrane Protein 1 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Putative Lipid Scramblase Clptm1 antibodyAnti-Cleft Lip And Palate Transmembrane Protein 1 antibodyAnti-CLPTM1 antibody |
Information sourced from Uniprot.org