Anti-CLPP antibody (57-277) (STJ111581)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLPP (57-277) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPP |
| Gene ID | 8192 |
| Uniprot ID | CLPP_HUMAN |
| Immunogen Region | 57-277 |
| Immunogen Sequence | PLIPIVVEQTGRGERAYDIY SRLLRERIVCVMGPIDDSVA SLVIAQLLFLQSESNKKPIH MYINSPGGVVTAGLAIYDTM QYILNPICTWCVGQAASMGS LLLAAGTPGMRHSLPNSRIM IHQPSGGARGQATDIAIQAE EIMKLKKQLYNIYAKHTKQS LQVIESAMERDRYMSPMEAQ EFGILDKVLVHPPQDGEDEP TLVQKEPVEAAPAAEPVPAS T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 57-277 of human CLPP (NP_006003.1). |
Additional Info
| Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. |
| Function | Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. |
| Protein Name | Atp-Dependent Clp Protease Proteolytic Subunit - MitochondrialCaseinolytic Mitochondrial Matrix Peptidase Proteolytic SubunitEndopeptidase Clp |
| Database Links | Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Atp-Dependent Clp Protease Proteolytic Subunit - Mitochondrial antibodyAnti-Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit antibodyAnti-Endopeptidase Clp antibodyAnti-CLPP antibody |
Information sourced from Uniprot.org