Anti-CLPB antibody (C-Term) (STJ71168)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CLPB (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave bands at approx 50kDa and 48kDa in lysates of HeLa and HepG2 after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPB |
| Gene ID | 81570 |
| Uniprot ID | CLPB_HUMAN |
| Accession Number | NP_110440.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | DKDSKTRRLDIRAP |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. |
| Function | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. |
| Protein Name | Mitochondrial DisaggregaseSuppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form |
| Cellular Localisation | Mitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Mitochondrial Disaggregase antibodyAnti-Suppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form antibodyAnti-CLPB antibodyAnti-SKD3 antibody |
Information sourced from Uniprot.org