Anti-CLPB antibody (458-707) (STJ113616)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLPB (458-707) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPB |
| Gene ID | 81570 |
| Uniprot ID | CLPB_HUMAN |
| Immunogen Region | 458-707 |
| Immunogen Sequence | KAHPDVLTIMLQLFDEGRLT DGKGKTIDCKDAIFIMTSNV ASDEIAQHALQLRQEALEMS RNRIAENLGDVQISDKITIS KNFKENVIRPILKAHFRRDE FLGRINEIVYFLPFCHSELI QLVNKELNFWAKRAKQRHNI TLLWDREVADVLVDGYNVHY GARSIKHEVERRVVNQLAAA YEQDLLPGGCTLRITVEDSD KQLLKSPELPSPQAEKRLPK LRLEIIDKDSKTRRLDIRA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1). |
Additional Info
| Tissue Specificity | Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes. |
| Post Translational Modifications | Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. |
| Function | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. |
| Protein Name | Mitochondrial DisaggregaseSuppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form |
| Database Links | |
| Cellular Localisation | Mitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Mitochondrial Disaggregase antibodyAnti-Suppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form antibodyAnti-CLPB antibodyAnti-SKD3 antibody |
Information sourced from Uniprot.org