Anti-CLN5 antibody (171-220 aa) (STJ92341)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLN5 at the amino acid range 171-220
General Information
| Short Description | Rabbit polyclonal anti-Ceroid-lipofuscinosis neuronal protein 5 (171-220 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLN5 |
| Gene ID | 1203 |
| Uniprot ID | CLN5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLN5 at the amino acid range 171-220 |
| Immunogen Region | 171-220 aa |
| Specificity | CLN5 Polyclonal Antibody detects endogenous levels of CLN5 protein. |
Additional Info
| Post Translational Modifications | N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. Bis(monoacylglycero)phosphate synthase CLN5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Bis(monoacylglycero)phosphate synthase CLN5, secreted form). Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end. |
| Function | Bis(monoacylglycero)phosphate synthase CLN5, secreted form: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. |
| Protein Name | Bis(Monoacylglycerophosphate Synthase Cln5Bmp Synthase Cln5Ceroid-Lipofuscinosis Neuronal Protein 5Protein Cln5Palmitoyl Protein Thioesterase Cln5S-Depalmitoylase Cln5 Cleaved Into - Bis(Monoacylglycerophosphate Synthase Cln5 - Secreted Form |
| Database Links | |
| Cellular Localisation | Bis(Monoacylglycero)Phosphate Synthase Cln5Secreted Form: LysosomeBis(Monoacylglycero)Phosphate Synthase Cln5: MembraneSingle-Pass Type Ii Membrane ProteinAn Amphipathic Anchor Region Facilitates Its Association With The Membrane |
| Alternative Antibody Names | Anti-Bis(Monoacylglycerophosphate Synthase Cln5 antibodyAnti-Bmp Synthase Cln5 antibodyAnti-Ceroid-Lipofuscinosis Neuronal Protein 5 antibodyAnti-Protein Cln5 antibodyAnti-Palmitoyl Protein Thioesterase Cln5 antibodyAnti-S-Depalmitoylase Cln5 Cleaved Into - Bis(Monoacylglycerophosphate Synthase Cln5 - Secreted Form antibodyAnti-CLN5 antibodyAnti-BMPS antibody |
Information sourced from Uniprot.org