| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ceroid-lipofuscinosis neuronal protein 5 (171-220 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLN5 |
| Gene ID: |
1203 |
| Uniprot ID: |
CLN5_HUMAN |
| Immunogen Region: |
171-220 aa |
| Specificity: |
CLN5 Polyclonal Antibody detects endogenous levels of CLN5 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CLN5 at the amino acid range 171-220 |
| Post Translational Modifications | N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. Ceroid-lipofuscinosis neuronal protein 5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form). Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end. |
| Function | Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. |
| Protein Name | Ceroid-Lipofuscinosis Neuronal Protein 5Protein Cln5 Cleaved Into - Ceroid-Lipofuscinosis Neuronal Protein 5 - Secreted Form |
| Cellular Localisation | Ceroid-Lipofuscinosis Neuronal Protein 5Secreted Form: LysosomeCeroid-Lipofuscinosis Neuronal Protein 5: MembraneSingle-Pass Type Ii Membrane ProteinAn Amphipathic Anchor Region Facilitates Its Association With The Membrane |
| Alternative Antibody Names | Anti-Ceroid-Lipofuscinosis Neuronal Protein 5 antibodyAnti-Protein Cln5 Cleaved Into - Ceroid-Lipofuscinosis Neuronal Protein 5 - Secreted Form antibodyAnti-CLN5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
