Anti-CLK3 antibody (STJ191969)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity protein kinase CLK3 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLK3 |
| Gene ID | 1198 |
| Uniprot ID | CLK3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CLK3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autophosphorylates on all three types of residues. |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Protein Name | Dual Specificity Protein Kinase Clk3Cdc-Like Kinase 3 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusCytoplasmCytoplasmic VesicleSecretory VesicleAcrosomeIsoform 2: Nucleus SpeckleCo-Localizes With Serine- And Arginine-Rich (Sr) Proteins In The Nuclear Speckles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Clk3 antibodyAnti-Cdc-Like Kinase 3 antibodyAnti-CLK3 antibody |
Information sourced from Uniprot.org