Anti-CLIC6 antibody (411-460 aa) (STJ92331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLIC6 at the amino acid range 411-460
General Information
| Short Description | Rabbit polyclonal anti-Chloride intracellular channel protein 6 (411-460 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLIC6 |
| Gene ID | 54102 |
| Uniprot ID | CLIC6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLIC6 at the amino acid range 411-460 |
| Immunogen Region | 411-460 aa |
| Specificity | CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. |
| Protein Name | Chloride Intracellular Channel Protein 6Glutaredoxin-Like Oxidoreductase Clic6Parchorin |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneSingle-Pass Membrane ProteinPredominantly CytoplasmicUpon Chloride Ion Efflux From The CellIt Is Translocated To The Plasma Membrane |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 6 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic6 antibodyAnti-Parchorin antibodyAnti-CLIC6 antibodyAnti-CLIC1L antibody |
Information sourced from Uniprot.org