Anti-CLEC6A antibody (Internal) (STJ97638)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human Dectin-2.
General Information
| Short Description | Rabbit polyclonal anti-C-type lectin domain family 6 member A (Internal) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC6A |
| Gene ID | 93978 |
| Uniprot ID | CLC6A_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human Dectin-2. |
| Immunogen Region | Internal |
| Specificity | Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein. |
Additional Info
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. |
| Protein Name | C-Type Lectin Domain Family 6 Member AC-Type Lectin Superfamily Member 10Dendritic Cell-Associated C-Type Lectin 2Dc-Associated C-Type Lectin 2Dectin-2 |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 6 Member A antibodyAnti-C-Type Lectin Superfamily Member 10 antibodyAnti-Dendritic Cell-Associated C-Type Lectin 2 antibodyAnti-Dc-Associated C-Type Lectin 2 antibodyAnti-Dectin-2 antibodyAnti-CLEC6A antibodyAnti-CLECSF10 antibodyAnti-DECTIN2 antibody |
Information sourced from Uniprot.org