• Western blot analysis of K562 using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
  • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • Western blot analysis of SH-SY5Y 293T using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Anti-CLEC6A antibody (Internal) (STJ97638)

SKU:
STJ97638

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C-type lectin domain family 6 member A (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLEC6A
Gene ID: 93978
Uniprot ID: CLC6A_HUMAN
Immunogen Region: Internal
Specificity: Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein.
Immunogen: Synthesized peptide derived from the Internal region of human Dectin-2.
Function Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
Protein Name C-Type Lectin Domain Family 6 Member A
C-Type Lectin Superfamily Member 10
Dendritic Cell-Associated C-Type Lectin 2
Dc-Associated C-Type Lectin 2
Dectin-2
Database Links Reactome: R-HSA-5621480
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-C-Type Lectin Domain Family 6 Member A antibody
Anti-C-Type Lectin Superfamily Member 10 antibody
Anti-Dendritic Cell-Associated C-Type Lectin 2 antibody
Anti-Dc-Associated C-Type Lectin 2 antibody
Anti-Dectin-2 antibody
Anti-CLEC6A antibody
Anti-CLECSF10 antibody
Anti-DECTIN2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance