Anti-CLEC5A/MDL1 antibody [DX246] {FITC} (STJA0028796)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Human monoclonal C-Type Lectin Domain Family 5 Member A antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | DX246 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | CLEC5A |
| Gene ID | 23601 |
| Uniprot ID | CLC5A_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release. |
| Protein Name | C-Type Lectin Domain Family 5 Member AC-Type Lectin Superfamily Member 5Myeloid Dap12-Associating Lectin 1Mdl-1 |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 5 Member A antibodyAnti-C-Type Lectin Superfamily Member 5 antibodyAnti-Myeloid Dap12-Associating Lectin 1 antibodyAnti-Mdl-1 antibodyAnti-CLEC5A antibodyAnti-CLECSF5 antibodyAnti-MDL1 antibody |
Information sourced from Uniprot.org