| Tissue Specificity | Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release. |
| Protein Name | C-Type Lectin Domain Family 5 Member AC-Type Lectin Superfamily Member 5Myeloid Dap12-Associating Lectin 1Mdl-1 |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 5 Member A antibodyAnti-C-Type Lectin Superfamily Member 5 antibodyAnti-Myeloid Dap12-Associating Lectin 1 antibodyAnti-Mdl-1 antibodyAnti-CLEC5A antibodyAnti-CLECSF5 antibodyAnti-MDL1 antibody |
Information sourced from Uniprot.org
