Anti-CLEC4A antibody (161-210 aa) (STJ98638)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human CLEC4A at the amino acid range 161-210
General Information
| Short Description | Rabbit polyclonal anti-C-type lectin domain family 4 member A (161-210 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC4A |
| Gene ID | 50856 |
| Uniprot ID | CLC4A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CLEC4A at the amino acid range 161-210 |
| Immunogen Region | 161-210 aa |
| Specificity | CLECSF6 Polyclonal Antibody detects endogenous levels of CLECSF6 |
Additional Info
| Function | C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. |
| Protein Name | C-Type Lectin Domain Family 4 Member AC-Type Lectin Ddb27C-Type Lectin Superfamily Member 6Dendritic Cell ImmunoreceptorLectin-Like ImmunoreceptorCd Antigen Cd367 |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinExtracellular Side |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member A antibodyAnti-C-Type Lectin Ddb27 antibodyAnti-C-Type Lectin Superfamily Member 6 antibodyAnti-Dendritic Cell Immunoreceptor antibodyAnti-Lectin-Like Immunoreceptor antibodyAnti-Cd Antigen Cd367 antibodyAnti-CLEC4A antibodyAnti-CLECSF6 antibodyAnti-DCIR antibodyAnti-LLIR antibodyAnti-HDCGC13P antibody |
Information sourced from Uniprot.org