• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-MMP19-Tyr98 antibody (97-98) (STJA0005890)

SKU:
STJA0005890

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Matrix metalloproteinase-19-Tyr98 (97-98) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMP19
Gene ID: 4327
Uniprot ID: MMP19_HUMAN
Immunogen Region: 97-98
Specificity: This antibody detects endogenous levels of Human, Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )
Immunogen: Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)
Post Translational Modifications Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK.
Function Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Protein Name Matrix Metalloproteinase-19
Mmp-19
Matrix Metalloproteinase Rasi
Matrix Metalloproteinase-18
Mmp-18
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Matrix Metalloproteinase-19 antibody
Anti-Mmp-19 antibody
Anti-Matrix Metalloproteinase Rasi antibody
Anti-Matrix Metalloproteinase-18 antibody
Anti-Mmp-18 antibody
Anti-MMP19 antibody
Anti-MMP18 antibody
Anti-RASI antibody

Information sourced from Uniprot.org

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