Anti-Cleaved-MMP19-Tyr98 antibody (97-98) (STJA0005890)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MMP19 (Cleaved-Tyr98)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Matrix metalloproteinase-19-Tyr98 (97-98) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP19 |
| Gene ID | 4327 |
| Uniprot ID | MMP19_HUMAN |
| Immunogen | Synthesized peptide derived from human MMP19 (Cleaved-Tyr98) |
| Immunogen Region | 97-98 |
| Specificity | This antibody detects endogenous levels of Human, Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 ) |
Additional Info
| Post Translational Modifications | Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
| Protein Name | Matrix Metalloproteinase-19Mmp-19Matrix Metalloproteinase RasiMatrix Metalloproteinase-18Mmp-18 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-19 antibodyAnti-Mmp-19 antibodyAnti-Matrix Metalloproteinase Rasi antibodyAnti-Matrix Metalloproteinase-18 antibodyAnti-Mmp-18 antibodyAnti-MMP19 antibodyAnti-MMP18 antibodyAnti-RASI antibody |
Information sourced from Uniprot.org