Anti-Cleaved-MASP1-Ile449, Light Chain antibody (448-449) (STJA0005850)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MASP1 (light chain, Cleaved-Ile449)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Mannan-binding lectin serine protease 1-Ile449, Light Chain (448-449) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MASP1 |
| Gene ID | 5648 |
| Uniprot ID | MASP1_HUMAN |
| Immunogen | Synthesized peptide derived from human MASP1 (light chain, Cleaved-Ile449) |
| Immunogen Region | 448-449 |
| Specificity | This antibody detects endogenous levels of Human MASP1 (light chain, Cleaved-Ile449, protein was cleaved amino acid sequence between 448-449 ) |
Additional Info
| Tissue Specificity | Protein of the plasma which is primarily expressed by liver. |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. N-glycosylated. Some N-linked glycan are of the complex-type. Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing. |
| Function | Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development. |
| Protein Name | Mannan-Binding Lectin Serine Protease 1Complement Factor Masp-3Complement-Activating Component Of Ra-Reactive FactorMannose-Binding Lectin-Associated Serine Protease 1Masp-1Mannose-Binding Protein-Associated Serine ProteaseRa-Reactive Factor Serine Protease P100RarfSerine Protease 5 Cleaved Into - Mannan-Binding Lectin Serine Protease 1 Heavy Chain - Mannan-Binding Lectin Serine Protease 1 Light Chain |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-2855086Reactome: R-HSA-3000480Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannan-Binding Lectin Serine Protease 1 antibodyAnti-Complement Factor Masp-3 antibodyAnti-Complement-Activating Component Of Ra-Reactive Factor antibodyAnti-Mannose-Binding Lectin-Associated Serine Protease 1 antibodyAnti-Masp-1 antibodyAnti-Mannose-Binding Protein-Associated Serine Protease antibodyAnti-Ra-Reactive Factor Serine Protease P100 antibodyAnti-Rarf antibodyAnti-Serine Protease 5 Cleaved Into - Mannan-Binding Lectin Serine Protease 1 Heavy Chain - Mannan-Binding Lectin Serine Protease 1 Light Chain antibodyAnti-MASP1 antibodyAnti-CRARF antibodyAnti-CRARF1 antibodyAnti-PRSS5 antibody |
Information sourced from Uniprot.org