| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Kallikrein-6-Leu22 (21-22) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-p 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLK6 |
| Gene ID: |
5653 |
| Uniprot ID: |
KLK6_HUMAN |
| Immunogen Region: |
21-22 |
| Specificity: |
This antibody detects endogenous levels of Human Kallikrein-6 (Cleaved-Leu22, protein was cleaved amino acid sequence between 21-22 ) |
| Immunogen: |
Synthesized peptide derived from human Kallikrein-6 (Cleaved-Leu22) |
| Post Translational Modifications | Inactivated by autolytic cleavage after Arg-80. |
| Function | Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. |
| Protein Name | Kallikrein-6NeurosinProtease MSp59Serine Protease 18Serine Protease 9Zyme |
| Cellular Localisation | SecretedNucleusNucleolusCytoplasmMitochondrionMicrosomeIn BrainDetected In The Nucleus Of Glial Cells And In The Nucleus And Cytoplasm Of NeuronsDetected In The Mitochondrial And Microsomal Fractions Of Hek-293 Cells And Released Into The Cytoplasm Following Cell Stress |
| Alternative Antibody Names | Anti-Kallikrein-6 antibodyAnti-Neurosin antibodyAnti-Protease M antibodyAnti-Sp59 antibodyAnti-Serine Protease 18 antibodyAnti-Serine Protease 9 antibodyAnti-Zyme antibodyAnti-KLK6 antibodyAnti-PRSS18 antibodyAnti-PRSS9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
