• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-Cleaved-ITIH4-R661 antibody (612-661 aa) (STJ90094)

SKU:
STJ90094

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H4-R661 (612-661 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITIH4
Gene ID: 3700
Uniprot ID: ITIH4_HUMAN
Immunogen Region: 612-661 aa
Specificity: Cleaved-ITI-H4 70k (R661) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H4 70k protein resulting from cleavage adjacent to R661.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ITIH4 at the amino acid range 612-661
Post Translational Modifications Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma.
Function Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
Protein Name Inter-Alpha-Trypsin Inhibitor Heavy Chain H4
Iti Heavy Chain H4
Iti-Hc4
Inter-Alpha-Inhibitor Heavy Chain 4
Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein
Ihrp
Plasma Kallikrein Sensitive Glycoprotein 120
Gp120
Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4
Database Links Reactome: R-HSA-114608
Cellular Localisation Secreted
Alternative Antibody Names Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibody
Anti-Iti Heavy Chain H4 antibody
Anti-Iti-Hc4 antibody
Anti-Inter-Alpha-Inhibitor Heavy Chain 4 antibody
Anti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibody
Anti-Ihrp antibody
Anti-Plasma Kallikrein Sensitive Glycoprotein 120 antibody
Anti-Gp120 antibody
Anti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibody
Anti-ITIH4 antibody
Anti-IHRP antibody
Anti-ITIHL1 antibody
Anti-PK120 antibody
Anti-PRO1851 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance