| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H4-R661 (612-661 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITIH4 |
| Gene ID: | 3700 |
| Uniprot ID: | ITIH4_HUMAN |
| Immunogen Region: | 612-661 aa |
| Specificity: | Cleaved-ITI-H4 70k (R661) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H4 70k protein resulting from cleavage adjacent to R661. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ITIH4 at the amino acid range 612-661 |
| Post Translational Modifications | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| Function | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 Iti Heavy Chain H4 Iti-Hc4 Inter-Alpha-Inhibitor Heavy Chain 4 Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein Ihrp Plasma Kallikrein Sensitive Glycoprotein 120 Gp120 Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibody Anti-Iti Heavy Chain H4 antibody Anti-Iti-Hc4 antibody Anti-Inter-Alpha-Inhibitor Heavy Chain 4 antibody Anti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibody Anti-Ihrp antibody Anti-Plasma Kallikrein Sensitive Glycoprotein 120 antibody Anti-Gp120 antibody Anti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibody Anti-ITIH4 antibody Anti-IHRP antibody Anti-ITIHL1 antibody Anti-PK120 antibody Anti-PRO1851 antibody |
Information sourced from Uniprot.org