Anti-Cleaved-ITIH4-R661 antibody (612-661 aa) (STJ90094)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ITIH4 at the amino acid range 612-661
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H4-R661 (612-661 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITIH4 |
| Gene ID | 3700 |
| Uniprot ID | ITIH4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ITIH4 at the amino acid range 612-661 |
| Immunogen Region | 612-661 aa |
| Specificity | Cleaved-ITI-H4 70k (R661) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H4 70k protein resulting from cleavage adjacent to R661. |
Additional Info
| Post Translational Modifications | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| Function | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H4Iti Heavy Chain H4Iti-Hc4Inter-Alpha-Inhibitor Heavy Chain 4Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related ProteinIhrpPlasma Kallikrein Sensitive Glycoprotein 120Gp120Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-Iti Heavy Chain H4 antibodyAnti-Iti-Hc4 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 4 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibodyAnti-Ihrp antibodyAnti-Plasma Kallikrein Sensitive Glycoprotein 120 antibodyAnti-Gp120 antibodyAnti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-ITIH4 antibodyAnti-IHRP antibodyAnti-ITIHL1 antibodyAnti-PK120 antibodyAnti-PRO1851 antibody |
Information sourced from Uniprot.org