Anti-Cleaved-ITIH2-D702 antibody (653-702 aa) (STJ90093)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ITIH2 at the amino acid range 653-702
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H2-D702 (653-702 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITIH2 |
| Gene ID | 3698 |
| Uniprot ID | ITIH2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ITIH2 at the amino acid range 653-702 |
| Immunogen Region | 653-702 aa |
| Specificity | Cleaved-ITI-H2 (D702) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H2 protein resulting from cleavage adjacent to D702. |
Additional Info
| Post Translational Modifications | Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated by FAM20C in the extracellular medium. |
| Function | May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H2Iti Heavy Chain H2Iti-Hc2Inter-Alpha-Inhibitor Heavy Chain 2Inter-Alpha-Trypsin Inhibitor Complex Component IiSerum-Derived Hyaluronan-Associated ProteinShap |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 antibodyAnti-Iti Heavy Chain H2 antibodyAnti-Iti-Hc2 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 2 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Complex Component Ii antibodyAnti-Serum-Derived Hyaluronan-Associated Protein antibodyAnti-Shap antibodyAnti-ITIH2 antibodyAnti-IGHEP2 antibody |
Information sourced from Uniprot.org