Anti-Cleaved-ITGA8-Arg906, Heavy Chain antibody (906-907) (STJA0005874)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ITGA8 (heavy chain, Cleaved-Arg906)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Integrin alpha-8-Arg906, Heavy Chain (906-907) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITGA8 |
| Gene ID | 8516 |
| Uniprot ID | ITA8_HUMAN |
| Immunogen | Synthesized peptide derived from human ITGA8 (heavy chain, Cleaved-Arg906) |
| Immunogen Region | 906-907 |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat ITGA8 (heavy chain, Cleaved-Arg906, protein was cleaved amino acid sequence between 906-907 ) |
Additional Info
| Tissue Specificity | Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). |
| Function | Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. |
| Protein Name | Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-216083Reactome: R-HSA-2173789Reactome: R-HSA-3000178Reactome: R-HSA-9830674 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain antibodyAnti-ITGA8 antibody |
Information sourced from Uniprot.org