Anti-Cleaved-ITGA6-Arg938, Heavy Chain antibody (938-939) (STJA0005873)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ITGA6 (heavy chain, Cleaved-Arg938)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Integrin alpha-6-Arg938, Heavy Chain (938-939) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITGA6 |
| Gene ID | 3655 |
| Uniprot ID | ITA6_HUMAN |
| Immunogen | Synthesized peptide derived from human ITGA6 (heavy chain, Cleaved-Arg938) |
| Immunogen Region | 938-939 |
| Specificity | This antibody detects endogenous levels of Human ITGA6 (heavy chain, Cleaved-Arg938, protein was cleaved amino acid sequence between 938-939 ) |
Additional Info
| Post Translational Modifications | Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p). Production of alpha6p enhances prostate cancer cell invasion and migration. Palmitoylation by DHHC3 enhances stability and cell surface expression. |
| Function | Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
| Protein Name | Integrin Alpha-6Cd49 Antigen-Like Family Member FVla-6Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6Alpha6p |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-446107Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-Anchor |
| Alternative Antibody Names | Anti-Integrin Alpha-6 antibodyAnti-Cd49 Antigen-Like Family Member F antibodyAnti-Vla-6 antibodyAnti-Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6 antibodyAnti-Alpha6p antibodyAnti-ITGA6 antibody |
Information sourced from Uniprot.org