| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Integrin alpha-3-Phe33, Heavy Chain (32-33) is suitable for use in Western Blot, Immunofluorescence, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IF ICC 1:50-200ELISA 1:2000-20000IHC-p 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITGA3 |
| Gene ID: |
3675 |
| Uniprot ID: |
ITA3_HUMAN |
| Immunogen Region: |
32-33 |
| Specificity: |
This antibody detects endogenous levels of Human, Mouse, Rat ITGA3 (heavy chain, Cleaved-Phe33, protein was cleaved amino acid sequence between 32-33 ) |
| Immunogen: |
Synthesized peptide derived from human ITGA3 (heavy chain, Cleaved-Phe33) |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. |
| Post Translational Modifications | Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. |
| Function | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. |
| Protein Name | Integrin Alpha-3Cd49 Antigen-Like Family Member CFrp-2Galactoprotein B3Gapb3Vla-3 Subunit AlphaCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-8874081 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-AnchorCell ProjectionInvadopodium MembraneFilopodium MembraneEnriched Preferentially At InvadopodiaCell Membrane Protrusions That Correspond To Sites Of Cell InvasionIn A Collagen-Dependent Manner |
| Alternative Antibody Names | Anti-Integrin Alpha-3 antibodyAnti-Cd49 Antigen-Like Family Member C antibodyAnti-Frp-2 antibodyAnti-Galactoprotein B3 antibodyAnti-Gapb3 antibodyAnti-Vla-3 Subunit Alpha antibodyAnti-Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain antibodyAnti-ITGA3 antibodyAnti-MSK18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
