Anti-Cleaved-F8-Ser760 antibody (STJA0005862)

SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FA8B (Cleaved-Ser760)
STJA0005862
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General Information

Short DescriptionRabbit polyclonal anti-Cleaved-Coagulation factor VIII-Ser760 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsWB/ELISA
HostRabbit
ReactivityHuman/Mouse
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityPolyclonal
IsotypeIgG
ConjugationUnconjugated
Concentration1 mg/mL
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Dilution RangeWB 1:1000-2000
ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage InstructionStore at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene SymbolF8
Gene ID2157
Uniprot IDFA8_HUMAN
ImmunogenSynthesized peptide derived from human FA8B (Cleaved-Ser760)
SpecificityThis antibody detects endogenous levels of Human, Mouse FA8B (Cleaved-Ser760, protein was cleaved amino acid sequence between )

Additional Info

Post Translational Modifications Sulfation on Tyr-1699 is essential for binding vWF. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
Function Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
Protein Name Coagulation Factor Viii
Antihemophilic Factor
Ahf
Procoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-140875
Reactome: R-HSA-163841
Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-9672383
Reactome: R-HSA-9672387
Reactome: R-HSA-9672391
Reactome: R-HSA-9672393
Reactome: R-HSA-9672395
Reactome: R-HSA-9672396
Reactome: R-HSA-9672397
Reactome: R-HSA-9673202
Reactome: R-HSA-9674519
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Coagulation Factor Viii antibody
Anti-Antihemophilic Factor antibody
Anti-Ahf antibody
Anti-Procoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain antibody
Anti-F8 antibody
Anti-F8C antibody

Information sourced from Uniprot.org

Citations

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