Anti-Cleaved-F5-Arg737, Heavy Chain antibody (737-738) (STJA0005835)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FA5 (heavy chain, Cleaved-Arg737)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Coagulation factor V-Arg737, Heavy Chain (737-738) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | F5 |
| Gene ID | 2153 |
| Uniprot ID | FA5_HUMAN |
| Immunogen | Synthesized peptide derived from human FA5 (heavy chain, Cleaved-Arg737) |
| Immunogen Region | 737-738 |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat FA5 (heavy chain, Cleaved-Arg737, protein was cleaved amino acid sequence between 737-738 ) |
Additional Info
| Tissue Specificity | Plasma. |
| Post Translational Modifications | Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylated by FAM20C in the extracellular medium. |
| Function | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| Protein Name | Coagulation Factor VActivated Protein C CofactorProaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140875Reactome: R-HSA-204005Reactome: R-HSA-381426Reactome: R-HSA-5694530Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor V antibodyAnti-Activated Protein C Cofactor antibodyAnti-Proaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain antibodyAnti-F5 antibody |
Information sourced from Uniprot.org