Anti-Cleaved-CTSC-Asp395, Light Chain antibody (394-395) (STJA0005854)

SKU:
STJA0005854

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Dipeptidyl peptidase 1-Asp395, Light Chain (394-395) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTSC
Gene ID: 1075
Uniprot ID: CATC_HUMAN
Immunogen Region: 394-395
Specificity: This antibody detects endogenous levels of Human Dipeptidyl-peptidase 3 (light chain, Cleaved-Asp395, protein was cleaved amino acid sequence between 394-395 )
Immunogen: Synthesized peptide derived from human Dipeptidyl-peptidase 1 (light chain, Cleaved-Asp395)
Tissue Specificity Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
Post Translational Modifications N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes. In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
Function Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.
Protein Name Dipeptidyl Peptidase 1
Cathepsin C
Cathepsin J
Dipeptidyl Peptidase I
Dpp-I
Dppi
Dipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain Chain
Dipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy Chain
Dipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light Chain
Dipeptidyl Peptidase I Light Chain
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-2132295
Reactome: R-HSA-5694530
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Alternative Antibody Names Anti-Dipeptidyl Peptidase 1 antibody
Anti-Cathepsin C antibody
Anti-Cathepsin J antibody
Anti-Dipeptidyl Peptidase I antibody
Anti-Dpp-I antibody
Anti-Dppi antibody
Anti-Dipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain Chain antibody
Anti-Dipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy Chain antibody
Anti-Dipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light Chain antibody
Anti-Dipeptidyl Peptidase I Light Chain antibody
Anti-CTSC antibody
Anti-CPPI antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance