| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cleaved-Aggrecan core protein-Ala17 (16-17) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-p 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACAN |
| Gene ID: | 176 |
| Uniprot ID: | PGCA_HUMAN |
| Immunogen Region: | 16-17 |
| Specificity: | This antibody detects endogenous levels of Human, Rat PGCA (Cleaved-Ala17, protein was cleaved amino acid sequence between 16-17) |
| Immunogen: | Synthesized peptide derived from human PGCA (Cleaved-Ala17) |
| Tissue Specificity | Detected in fibroblasts (at protein level). Restricted to cartilage. |
| Post Translational Modifications | Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. |
| Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
| Protein Name | Aggrecan Core ProteinCartilage-Specific Proteoglycan Core ProteinCspcpChondroitin Sulfate Proteoglycan Core Protein 1Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3000178Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Aggrecan Core Protein antibodyAnti-Cartilage-Specific Proteoglycan Core Protein antibodyAnti-Cspcp antibodyAnti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibodyAnti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibodyAnti-ACAN antibodyAnti-AGC1 antibodyAnti-CSPG1 antibodyAnti-MSK16 antibody |
Information sourced from Uniprot.org
