Anti-CLDN8 antibody (81-130 aa) (STJ92323)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLDN8 at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-Claudin-8 (81-130 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN8 |
| Gene ID | 9073 |
| Uniprot ID | CLD8_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLDN8 at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | Claudin-8 Polyclonal Antibody detects endogenous levels of Claudin-8 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-8 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinLocalizes To Tight Junctions In All 3 Segments Of The EpididymisIn The Caput Found In The Lateral Margins Of Principal CellsAnd In The Corpus At The Interface Between Basal And Principal Cells |
| Alternative Antibody Names | Anti-Claudin-8 antibodyAnti-CLDN8 antibodyAnti-UNQ779 antibodyAnti-PRO1573 antibody |
Information sourced from Uniprot.org