Anti-CLDN6 antibody (119-219) [S5280RM] (STJ11105280)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Claudin-6 (119-219) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5280RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:3000-1:12000IHC-P:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN6 |
| Gene ID | 9074 |
| Uniprot ID | CLD6_HUMAN |
| Immunogen Region | 119-219 |
| Immunogen Sequence | SGIVFVISGVLTLIPVCWTA HAIIRDFYNPLVAEAQKREL GASLYLGWAASGLLLLGGGL LCCTCPSGGSQGPSHYMARY STSAPAISRGPSEYPTKNYV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 119-219 of human Claudin 6 (NP_067018.2) |
Additional Info
| Tissue Specificity | Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. |
| Protein Name | Claudin-6Skullin |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-6 antibodyAnti-Skullin antibodyAnti-CLDN6 antibodyAnti-UNQ757 antibodyAnti-PRO1488 antibody |
Information sourced from Uniprot.org