| Host: | Mouse |
| Applications: | WB/IF/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Claudin-2 is suitable for use in Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IF ICC 1:100-500 IHC |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLDN2 |
| Gene ID: | 9075 |
| Uniprot ID: | CLD2_HUMAN |
| Specificity: | This antibody detects endogenous levels of human Claudin-2 |
| Immunogen: | Synthesized peptide derived from the human Claudin-2 |
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response. In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream. In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients. |
| Protein Name | Claudin-2 Sp82 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell Junction Tight Junction Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-2 antibody Anti-Sp82 antibody Anti-CLDN2 antibody Anti-PSEC0059 antibody Anti-SP82 antibody Anti-UNQ705 antibody Anti-PRO1356 antibody |
Information sourced from Uniprot.org