| Host: |
Mouse |
| Applications: |
IHC/IF/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Claudin-2 (150-250 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2bk |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:100-300WB 1:500-2000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN2 |
| Gene ID: |
9075 |
| Uniprot ID: |
CLD2_HUMAN |
| Immunogen Region: |
150-250 aa |
| Specificity: |
This antibody detects endogenous levels of human Claudin 2 |
| Immunogen: |
Synthesized peptide derived from the human Claudin 2 at the amino acid range 150-250 |
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response. In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream. In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients. |
| Protein Name | Claudin-2Sp82 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-2 antibodyAnti-Sp82 antibodyAnti-CLDN2 antibodyAnti-PSEC0059 antibodyAnti-SP82 antibodyAnti-UNQ705 antibodyAnti-PRO1356 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
