Anti-CLDN16 antibody (STJA0008571)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Claudin 16
General Information
| Short Description | Rabbit polyclonal anti-Claudin-16 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN16 |
| Gene ID | 10686 |
| Uniprot ID | CLD16_HUMAN |
| Immunogen | Synthesized peptide derived from human Claudin 16 |
| Specificity | This antibody detects endogenous levels of Claudin 16 at Human, Mouse, Rat |
Additional Info
| Function | Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption. |
| Protein Name | Claudin-16Paracellin-1Pcln-1 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinCotrafficks With Cldn19 From Er To Tight Junctions |
| Alternative Antibody Names | Anti-Claudin-16 antibodyAnti-Paracellin-1 antibodyAnti-Pcln-1 antibodyAnti-CLDN16 antibodyAnti-PCLN1 antibody |
Information sourced from Uniprot.org