• Western blot analysis of lysates from HeLa cells, using Claudin 1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Claudin-1 Polyclonal Antibody diluted at 1:1000
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Claudin 1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of Hela cell. 1, Claudin-1 Polyclonal Antibody (green) was diluted at 1:200 (4°C overnight). 2, Goat Anti Rabbit Alexa Fluor 488 Catalog: (NA was diluted at 1:1000 (room temperature, 50min). 3 DAPI (blue) 10min.

Anti-CLDN1 antibody (162-211 aa) (STJ92307)

SKU:
STJ92307

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Claudin-1 (162-211 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:100-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLDN1
Gene ID: 9076
Uniprot ID: CLD1_HUMAN
Immunogen Region: 162-211 aa
Specificity: Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Claudin 1 at the amino acid range 162-211
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Protein Name Claudin-1
Senescence-Associated Epithelial Membrane Protein
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Associates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane
Alternative Antibody Names Anti-Claudin-1 antibody
Anti-Senescence-Associated Epithelial Membrane Protein antibody
Anti-CLDN1 antibody
Anti-CLD1 antibody
Anti-SEMP1 antibody
Anti-UNQ481 antibody
Anti-PRO944 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance